Monday: new diet.
By Thursday you're starving. By Saturday it's over. Again.
★★★★★ The newest approach to weight loss · now in Portugal
Lose the weight. Skip the diet.
No strict meal plan. No endless workouts. A new generation of weight-loss science works on the real reason diets fail: hunger. You simply want less, so the kilos come off without the daily fight. In a 48-week clinical trial it averaged 24% body-weight loss.1
No strict meal plan. No endless workouts. A new generation of weight-loss science turns down hunger itself. In a 48-week clinical trial it averaged 24% body-weight loss.1
Free 10-minute consultation with a specialist. Find out if it's right for you, with no cost and no obligation.
How much weight would you like to lose? Tap to book your free consultation.
- No meal plan to follow
- No hours at the gym
- Hunger and cravings turned down
- Real specialists, consultation in English
Free10 minutesNo obligation
24% average loss48-week clinical trial1
3 hunger signalsturned down at once
🧪Published clinical research
📞Free 10-min consultation
🇪🇺Ships from inside the EU
💬Real people, not bots
2-minute video
How it works, simply.
Three hunger signals, what the research found, and what to expect.
✓ Your answers are saved. Watch this, then book your free call.
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Free · 10 minutes · No obligation
Sound familiar?
You did everything right.
You did everything right.
The scale didn't care.
Hours at the gym.
Then hunger wins at 9 p.m. and quietly undoes the whole week.
The kilos come off…
…and come back, bringing a few friends with them.
It was never your willpower. When you eat less, your body fights back with hunger. That's biology. Diets ask you to win that fight every single day. The newest approach simply turns the hunger down.
Your numbers
What could you lose, without dieting harder?
BEFOREAFTER
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How much could you lose by next summer?
kg
60 kg180 kg
At the clinical trial average,
that's about
Calculated with the 24.2% average weight loss at the highest dose in a 48-week phase 2 clinical trial.1 Not a promise: results vary from person to person.
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The new approach
Don't fight hunger.
Don't fight hunger.
Turn it down.
Researchers found a way to work with the body's own fullness signals instead of against them. The newest compound, nicknamed “GLP-3”, acts on three of them at once. Earlier weight-loss medications act on one or two.
You feel full sooner
Meals end earlier, naturally. Half the plate is enough, and it doesn't feel like a sacrifice.
The cravings go quiet
The constant thinking about food, the 11 p.m. fridge visits, the "just one more": they fade.
Your body burns more
The signal earlier options don't touch, and a big reason researchers are so excited about it.
The proof
The results that made headlines.
Published in the New England Journal of Medicine. Each new generation added a hunger signal, and the average results climbed with it.
Average body-weight loss at the highest dose in each molecule's published trial: semaglutide STEP 1,2 tirzepatide SURMOUNT-1,3 retatrutide phase 2.1 These are separate trials with different lengths and participants, not a head-to-head comparison. The newest reached its figure in the shortest time.
Your free consultation
10 minutes. Zero pressure.
Not a sales line: a real conversation with a specialist about your goal, and whether the new approach fits you.
Synthosonline
Hi Ana! This is Rita from Synthos 👋 You asked about losing 10–20 kg.
Is now a good time for a quick 10-minute call? I'll explain how it works.
Yes! Does it really work without a diet?
It works on hunger itself, so most people simply eat less without trying. Calling you now 🙂
What to expect
What people notice first.
Based on what was reported in the clinical research. Everyone is different.
The noise gets quiet
Hunger and food thoughts calm down. This is usually the first thing people mention.
Portions shrink
You eat less without planning to, and the weight starts to follow.
Steady progress
In the trial, weight kept coming down across the full 48 weeks.1
Common side effects
Nausea, diarrhoea or constipation were the most common, mostly mild and early on.1
Book your free consultation
10 minutes with a specialist. Find out if the new approach fits you. No cost, no obligation.
FAQ
Straight answers.
Everything people ask before their consultation.
What is this new approach?
A new generation of weight-loss science that works on hunger itself instead of asking you to fight it. The compound behind it, retatrutide (often called “GLP-3”, or Reta), acts on three of the body's hunger and metabolism signals: GLP-1, GIP and glucagon. Your specialist explains exactly how it works on the call.
Do I need to diet or work out?
There's no strict meal plan and no training programme. Most people simply find they want less food. Eating sensibly and moving more still help, but you're no longer fighting hunger all day.
How much could I lose, and how fast?
Results vary a lot from person to person. In the 48-week phase 2 clinical trial, the highest dose averaged 24.2% body-weight loss, and weight kept coming down across the whole study.¹ The calculator above uses that average to give you a rough idea, not a promise.
What happens on the free consultation?
A specialist calls or messages you for about 10 minutes, in English. They ask about your goal, explain how it works, what to expect and the side effects, and answer every question. There's no obligation to buy anything.
How much does it cost?
Your specialist explains the options and the price on the call. The consultation itself is free.
Is it approved?
No. Retatrutide is still in clinical trials and is not approved by the EMA or Infarmed. It is supplied for research purposes only, to adults aged 18 and over. Speak to a doctor before making changes to your health.
What side effects were reported in the research?
The most common were digestive: nausea, diarrhoea, vomiting and constipation, mostly mild to moderate and more frequent at the start. Some participants had a higher resting heart rate. Your specialist goes through them with you.
How is it delivered?
As a ready-to-use pre-filled pen with 12 needles, in a plain, tracked box shipped from inside the EU. No customs and no fees at the door; delivery takes 2–5 working days.
Who will call me?
A real Synthos specialist, not a bot. The consultation is in English. After the call they stay with you on WhatsApp.
Your next step
Ready to lose the weight
Ready to lose the weight
without the diet?
Book your free 10-minute consultation. No cost, no obligation, no meal plan.
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